After suffering some side-effects from his spider bite, Peter Parker decides to use the scientific method to figure out what is happening to him.

Peter Parker is accepted into Horizon High - a high school for brilliant young scientific minds. He struggles with the duality of his social life at school and hiding his secret identity of Spider-Man from everyone including his best friend, Harry Osborn, who attends the competing Osborn Academy for Geniuses. As Peter embraces his alter-ego, and battles against super villains like Vulture, Lizard, Doc Ock and Hammerhead, he is forced to watch Harry slowly descend to the wrong side of good and evil.

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