A structural damage to a building demolishes itself with people inside House is put on the case to save one survivor but her symptoms don't seem to add up and House can't figure out why.

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Season 4 Episode1 "Alone"
When an office building collapses, House has to work fast to diagnose a young woman, Megan (Bevin Prince), who has managed to survive the disaster. Without a team, House talks through his ideas with a janitor at Princeton-Plainsboro. As House persists in diagnosing Megan by himself, he soon realizes the case is not what it appears to be and that solitude may not be the answer.


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