After playing together for nearly five decades, these are some of the greatest hardships the members of U2 have faced throughout their careers.

#U2 #Bono #Bands

Bono lost his mother early | 0:00
Larry Mullen Jr.'s early losses | 1:07
Adam Clayton's substance abuse | 2:06
They've endured musical differences | 3:10
A lacking Irish fanbase | 4:19
The Spider-Man musical flopped | 5:22
Bono's been injured several times | 6:30
Bono suffers from glaucoma | 7:07
Bono's nearly fatal heart condition | 8:10
The Edge lost his grandson | 9:04
Performing without Larry Mullen | 9:51

Voiceover by: Jarman Day

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